Lupus Medication Side Effects:
What You Should Know

Lupus Medication Side Effects

Living with lupus brings many challenges, including managing the medicines that help control symptoms. While these medicines are essential, they can sometimes cause side effects. Knowing what to watch for and spotting side effects early is important to avoid discomfort or more serious health problems. Many people with lupus worry about how their medications might affect them over time, and understanding these effects can give you greater control over your health.

Assorted lupus medications and supplies arranged around the word “LUPUS” on a blue background.

At Brickell Rheumatology Wellness Center, we listen to these concerns and work closely with each patient. Our team provides personalized guidance about lupus medications and their possible side effects to support your well-being.

Get a Lupus Treatment Plan That Is Tailored to You

Call Brickell Rheumatology Wellness Center at (305) 928-6001 Today!

What is Lupus and Why Do You Need Medication?

Lupus is a chronic condition where the immune system mistakenly attacks the body’s own tissues. This can cause inflammation, pain, and damage to organs such as the skin, kidneys, and joints. To manage lupus, medications that suppress or modify the immune system are often prescribed to reduce symptoms and prevent flare-ups. Because these medicines affect the immune system, they can sometimes cause side effects. Recognizing these effects early helps protect your health.

Common Lupus Medications and Their Side Effects

Different types of medications are used to treat lupus, and each may have its own side effects to watch for:

Antimalarials (e.g., hydroxychloroquine)

  • Nausea, vomiting, stomach pain
  • Diarrhea
  • Headache or dizziness
  • Skin rash or changes in vision

Note: Rarely, hydroxychloroquine can affect your retina. It’s important to have baseline and regular eye exams as recommended by your doctor.

Corticosteroids (e.g., prednisone)

  • Weight gain
  • Easy bruising
  • Mood changes such as irritability or anxiety
  • Thinning bones (osteoporosis)
  • Higher risk of infections
  • High blood pressure
  • High blood sugar or diabetes
  • Eye issues like cataracts or glaucoma

Immunosuppressants (e.g., methotrexate, azathioprine, mycophenolate)

  • Nausea and vomiting
  • Increased sensitivity to sunlight
  • Hair thinning or hair loss
  • Higher risk of infections
  • Possible liver problems and low blood counts (monitored with blood tests)

Biologic therapies (e.g., belimumab)

  • Fever or chills
  • Headache
  • Nausea or diarrhea
  • Runny or stuffy nose
  • Injection site reactions, such as redness and swelling

Note: Belimumab can increase your risk of infections. Inform your doctor if you have a fever, new symptoms, or mood changes, including depression.

Why Monitoring Side Effects Is Important

Side effects can be mild or more serious. Some resolve over time, while others may require changes to your treatment. Always tell your healthcare provider about any side effects so they can adjust your medication or provide treatment. Regular lab tests and checkups help monitor side effects. For example, eye exams can catch early retinal changes from hydroxychloroquine use, and blood tests monitor liver function and blood cell counts during immunosuppressant therapy.

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Warning Signs to Watch For

Seek immediate medical care if you experience any of these:

  • Severe stomach pain or ongoing nausea and vomiting
  • New or worsening rash, swelling, or itching
  • Trouble breathing or shortness of breath
  • Chest pain
  • Unusual bleeding or bruising
  • Yellowing skin or eyes (jaundice)
  • High fever or signs of infection
  • Changes in vision, such as blurred vision or vision loss
  • Muscle weakness or numbness
  • Mood changes or signs of depression
  • Irregular heartbeat or dizziness

How to Manage Lupus Medication Side Effects

Working with your healthcare team is key to balancing effective lupus treatment with manageable side effects. Here’s what you can do:

  • Take medications exactly as prescribed.
  • Never stop or change medication without your doctor’s advice.
  • Report side effects promptly.
  • Keep a diary of symptoms to discuss during visits.
  • Attend all medical appointments and recommended tests.
  • Ask your doctor about vaccines before starting certain medicines.
  • Take prescribed supplements like vitamins or folic acid as directed.
  • Protect your skin from the sun using clothing and sunscreen, since sun exposure can worsen lupus and cause sensitivity to some drugs.
  • Eat a healthy diet and stay hydrated.
  • Avoid alcohol and tobacco, which may amplify side effects.
  • Rest when tired and avoid overexertion.

Frequently Asked Questions

  • What Side Effects Can Lupus Medications Cause?

Side effects vary by medication. Common ones include nausea, fatigue, weight gain, and increased infections. Corticosteroids may cause mood changes and high blood pressure. Immunosuppressants can weaken the immune system and affect the liver and blood counts; some medicines (e.g., calcineurin inhibitors) may also affect the kidneys. Regular checkups help manage side effects early.


  • Are There Supplements I Should Avoid?

Some supplements interact with lupus or medications. Alfalfa is often discouraged because it may worsen lupus symptoms. Garlic and high-dose vitamin E can increase bleeding risk, especially if you take blood thinners. Always consult your doctor before taking supplements.


  • Is Taking Hydroxychloroquine Safe and Effective?

Hydroxychloroquine is generally safe and effective when taken as prescribed and monitored. It may cause stomach cramps, headaches, or dizziness. The main long-term risk is eye damage, which can be detected early by regular eye exams.

Personalized Lupus Care

Brickell Rheumatology Lupus Medication Side Effects What You Should Know 2 | Brickell Rheumatology Wellness Center

Understanding the side effects of lupus medication helps patients take control of their health. At Brickell Rheumatology Wellness Center, patients receive personalized guidance to safely manage their lupus care. Regular checkups and open communication about side effects enable medications to help without causing harm. Contact Brickell Rheumatology Wellness Center for support with lupus treatment and side effect management. Our caring team is here to help patients live healthier, more comfortable lives despite the challenges of lupus.

Schedule Your Lupus Medication Review

Call Brickell Rheumatology Wellness Center at (305) 928-6001 Today!

Medical Disclaimer: The information provided in this content is intended solely for general informational and educational purposes. It does not constitute medical advice, diagnosis, or treatment recommendations. Do not act upon or rely on any information contained herein without first consulting a licensed healthcare professional regarding your specific medical condition or concerns.

Health conditions and treatment needs vary from person to person. What is appropriate for one individual may not be suitable for another. Always seek guidance from your physician or another qualified healthcare provider before making decisions about your health, starting or stopping any treatment, or changing medications. Never disregard professional medical advice or delay seeking care because of something you have read in this content. In the event of a medical emergency, contact your physician, call 911, or visit the nearest emergency facility immediately.

For information regarding your rights as a patient in Florida, please refer to Florida’s legislation or regulations outlining your rights and responsibilities as a patient.

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